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《Journal of Third Military Medical University》 2013-02
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Sepsis treatment——Challenge and chance

Zhou Hong1,Liu Xin2,Zheng Jiang2(1Department of Pharmacology,College of Pharmacy,2Medical Research Center,Southwest Hospital,Third Military Medical University,Chongqing,400038,China)  
Sepsis-related organ dysfunction and shock are primary causes of death in critical illness,which is triggered by pathogen associated molecules patterns(PAMPs) and progresses into life threatening stages as a result of systemic dysfunction in inflammatory reactions,coagulation cascades and immune responses.Advances in our understanding of pathogenesis in sepsis prompt different kinds of anti-sepsis strategies.Unfortunately,there is no specific agent for sepsis except for recombinant human activated protein C,which is withdrawn because of its severe adverse effects.Therefore,it is significant to reevaluate the drugs in clinic and reconsider the strategies in preclinical or clinical studies.Herein,we discuss the therapeutic approaches for sepsis that affect different stages of sepsis progression,their efficacy in treating sepsis,and possible fields for discovering new agents for sepsis treatment.
【Fund】: 国家自然科学基金(30973545)~~
【CateGory Index】: R459.7
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【References】
Chinese Journal Full-text Database 1 Hits
1 HOU Fei;WANG Li-kui;WANG Hong;Department of Infection,Beijing Friendship Hospital,Capital Medical University;Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences;;Study on gene expression of S100A12 protein in whole blood of patients with sepsis[J];Journal of Clinical and Experimental Medicine;2013-23
【Co-references】
Chinese Journal Full-text Database 2 Hits
1 LI Shao - hong1,BU Hui - ju2, ZHONG Jian1,et al. 1 Department of Emergency; 2 ICU,Donghua Hospital,Dongguan Guangdong 523110,China.;Clinical research of lactic acid,pro - calcionin and D - dimer in estimating the sepsis patients' prognosis[J];Journal of Clinical and Experimental Medicine;2013-12
2 ZHOU Rong-bin,ZHOU Gao-su.Emergency Department,Beijing Military General Hospital,Beijing 100700,China;Diagnostic methods of septic infection[J];Chinese Journal of Critical Care Medicine;2008-01
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