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《Journal of Third Military Medical University》 2018-01
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Efficiency of methazolamide for hypoxia tolerance in mice and its prevention for acute mountain sickness

XU Gang;HUANG He;CHEN Dewei;GUAN Libin;SUN Binda;HU Qiu;JIANG Chunhua;LUO Yongjun;LIU Fuyu;GAO Yuqi;Department of Medicine and Hygienic Equipment for High Altitude Region,Third Military Medical University;Key Laboratory of High Altitude Medicine,College of High Altitude Military Medicine,Third Military Medical University;Department of Pathophysiology and High Altitude Pathology,Third Military Medical University;  
Objective To study the anti-hypoxic effect of methazolamide(MTZ) and its prevention of acute high altitude reaction. Methods After the mice were intragastrically infused with MTZ,closed hypoxia experiment,myocardial hypoxia experiment,cerebral ischemia and hypoxia experiment and sodium nitrite poisoning experiment were used to determine the survival time in closed hypoxia,myocardial hypoxia tolerance time,mouth movement time after decapitation,and survival time of sodium nitrite poisoning. After the volunteers who took MTZ or placebo in high altitude,the heart rate,blood oxygen saturation and the incidence of acute altitude sickness were compared. Results The different doses of MTZ(400,200 and100 mg/kg) significantly prolonged the closed hypoxia survival time than the control mice without treatment[25. 01(2. 40),21. 11(4. 64) and 16. 39(5. 14) vs 14. 62(3. 62) min/100 m L,P 0. 05]. What's more,200 mg/kg MTZ also improved myocardial hypoxia tolerance time(13. 08 ± 1. 35 vs 8. 30 ± 0. 94 min/100 m L,P 0. 01) and mouth movement time after decapitation of mice(43. 22 ± 8. 23 vs 20. 44 ± 2. 60 s,P 0. 01).In clinic trial,MTZ treatment significantly decreased HR[100(17) vs 90(21. 5),P 0. 05],improve Sa O2[85%(4%) vs 87%(3. 5%),P 0. 01],and reduced the incidence rate of acute mountain sickness(19. 4% vs 3. 45%,P 0. 05) in the volunteers at high altitude. Conclusion MTZ improves body's ability to resist hypoxia and effectively prevents the occurrence of acute high-altitude disease.
【Fund】: 国家基础科学人才培养基金(J1310001)~~
【CateGory Index】: R594.3
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