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《Journal of Third Military Medical University》 2018-01
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Intracranial pressure monitoring guides the dose of propofol in anesthesia for craniocerebral trauma patients

YUAN Peng;YONG Haochuan;WANG Jia;TANG Yanming;ZOU Shengwei;CHEN Fei;HE Linfeng;WANG Enqin;TAO Guocai;Department of Neurosurgery,Emergency Medical Center of Chongqing;Department of Anesthesiology,Jilin Provincial Hospital of Traditional Chinese and Western Medicine;Department of Anesthesiology, Southwest Hospital, Third Military Medical University;  
Objective To guide the dose of propofol for anesthesia in craniocerebral trauma patients by self-designed multifunctional transcranial puncture for intracranial pressure monitoring. Methods A prospective randomized controlled study was designed on 68 patients with craniocerebral trauma. They were randomly divided into the conventional group and the experimental group(n = 34),with cerebral perfusion pressure(CPP) and intracranial pressure(ICP) to guide the dose of propofol before operation. The changes of ICP,CPP,systolic blood pressure(SBP),diastolic blood pressure(DBP),and mean arterial pressure(MAP) before anesthesia(T0),in induction(T1),1 h after operation(T2),2 h after operation(T3),and10 min before the end of surgery(T4) were measured and compared between the 2 groups. Results There were no significant differences in SBP,DBP,MAP,ICP and CPP between the 2 groups before anesthesia induction(P 0. 05). At T2 and T3,SBP,DBP,MAP,ICP and CPP were declined more significantly in the conventional group than the experimental group(P 0. 05). Conclusion Our designed multifunctional transcranial puncture can effectively monitor ICP and CPP and guide the dose of propofol for craniocerebral trauma patients. It is worthy of further clinical promotion.
【Fund】: 国家自然科学基金面上项目(81171034);; 重庆市卫计委医学科研重点项目(2013-1-041)~~
【CateGory Index】: R614
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