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《Journal of Third Military Medical University》 2018-06
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Correlation of CYP2C19~*2 polymorphism with clopidogrel resistance and risk of stroke recurrence in Uygur patients with ischemic stroke

HAO Chenguang;CAI Jian;Department of Neurology,the First Affiliated Hospital of Xinjiang Medical University;  
Objective To explore the relationship of CYP2 C19~*2 polymorphism with clopidogrel resistance and risk of stroke recurrence in Uygur patients. Methods The CYP2 C19~*2 genotype was detected in 100 patients with ischemic stroke. According to their genotypes,the patients were divided into wild type group,heterozygous mutation group and homozygous mutation group. Platelet inhibitory rates were evaluated by platelet analyzer. The incidence rate of stroke recurrence was observed in the patients after clopidogrel treatment for 6 months. Results According to their genotypes,there were 63 patients( 63%) assigned into wild type group,32( 32%) into heterozygous mutation group and 5( 5%) into homozygous mutation group.The rates of clopidrogel resistance and stroke recurrence were significantly higher in the mutation groups than the wild type group( P 0. 05). Logistic regression analysis showed the mutant allele of CYP2 C19~*2 was risk factor for clopidrogel resistance and stroke recurrence( OR = 2. 541,95% CI: 1. 052 ~ 6. 137,P = 0. 038;OR = 4. 741,95% CI: 1. 273 ~ 7. 392,P = 0. 045). Conclusion CYP2 C19~*2 gene polymorphisms are associated with clopidogrel resistance and stroke recurrence in Uygur patients with ischemic stroke. The mutant alleles of CYP2 C19~*2 is risk factor for clopidrogel resistance and stroke recurrence.
【Fund】: 新疆医科大学第一附属医院青年科学基金(2014ZRQN07)~~
【CateGory Index】: R743.3
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