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《Chinese Journal of Control of Endemic Disease》 1996-01
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THE NEW HYPOTHESIS ON THE ETIOLOGY OF KASHIN-BECK DISEASE-- THE CHONDROSULPHATASE-PRODUCING ANAEROBES IS THE MAIN PATHO-GENETIC CAUSE OF KASHIN-BECK DISEASE

Tan Xushu, Qingdao Medical College  
This article probes into the pathogenetic cause of KBD from KBD itself. On the basis of the results of animal experiments and on-the-spot investigations made in the four epidemic regions Yidu,Yongshou,Tianshui and Hanyuan,we propose a new hypothesis that the pollution of wa- ter sources made by anaerobes is the pathogenetic cause of KBD. In the water sources of epidemic regions contaminated with animal wastes,there are chondrosulphatase-producing anaerobes, which can destroy the chondroitin sulphate in the growing articular cartilage tissue after entering the human body,causing a series of pathogenetical changes in osteoarticulations. This new hypothesis has been proved by the results of the appearance of those early pathologic changes like hyperplasia and necroses in cartilages of epiphyseal plates of mice,which are identical with that of human KBD,and proved by the fact that no more new case has been reported after taking the measures of removing such pathogenetic factors by cleaning those water sources in epidemic areas.
【CateGory Index】: R684.1
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