EFFECT OF HICH FLUORINE AND SELENIUM ON PITUITARY GLAND, THYROID AND PARATHYROID IN THE RATS
Lu Chuanhua Shandong Institute for Prevention and Treatment of Endemic Disease,Jinan
In order to observe the effect of high fluorine (F)and the protection of selenium(Se)on pituitary gland,thyroid and parathyroid,wistar rat of 2 groups with chronic fluorosis were duplicated with 2 concentration F in the drinking water (1. 58,2. 63 mmol/L)and 2 groups were fed with Se fodders (2. 024mg/kg)and high F for 14 months. The results showed that in thyroid of optic microscope,there were pathological changes of wide-spread proliferation for 4 months and coexistence of proliferation and excessive rehabilitation for 8 and 14 months. Pituitary gland gave rise to the changes of the proliferation and the expansion in capillary, increase of quantity and size in acidophilic cells. At the same time,the proliferation and ascent of chief cells,of parathyroid gland were observed for 8 months. This suggested that(1)high F could damage these organs. (2)Se could antagonize high F but could not protect the organs of the rats with fluorosis.
【CateGory Index】： R599