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《Chinese Journal of Control of Endemic Disease》 1997-01
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EFFECTS OF OVER-FLUORIDE ON METABOLISM OF GLYCOSAMINOGLYCAN AND PROTEOGLYCAN IN CARTILAGE MATRIX

Piao Chunji,et al Institute of Preclimcal Sciences, N orman Bethune University of Medical Sciences  
Under the condition of monotonous diet and over-fluoride diet,the metabolism of proteogly-can(PG)and glycosaminoglycan(GAG)in rat cartilage tissue was seriously distorted. The contents of PG polymers in costicartilage matrix decreased significantly. The low polymers of PG increased and the molecular weight of PG monomers decreased significantly, respectively. The GAG content in cartilage matrix significantly increased at the same time. The results showed that over-fluoride can inhibit the PG anabolism and promote the PG catabolism.
【Fund】: 吉林省科委资助课题
【CateGory Index】: R363
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