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《Chinese Journal of Control of Endemic Disenaces》 2001-01
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Effect of superposition infection of CVB_4 and CVB_(3m) on T cell subgroups of Kunming mice with deficiency of Se

Wang Ying, Zhou Lingwang, Liu Hong, et al (Keshan Disease Institute of Harbin Universtity of Medical Sciences, harbin 150086)  
Objective To observe the changes of T cell subgroups of with Se deficiency and Se supplement 7 days after superposition infection of CVB4 and CVB3m. Methods After foe mice have been infected with CVB4 and CVB3m, we have observed the amount of T cell subgroups of mice and neutralization antibody of the serum and virus titre of the myocardium. Result The results show that in the Se deficiency group CD4, CD8 and CD3 amount have decreased, but in the Se supplement group CD4, CD8 and CD3 amount have increased obviously. In the Se deficiency group degree of pathological changes of cardiac muscle is more seriously than in Se supplement group, and virus titre of the myocardium higher than in Se deficiency group. Conclusion It has been concluded that Se deficency could induce decline of the immunity function, and superposition infection of CVB4 and CVB3m induce further decline of the immunity function.
【Fund】: 国家自然基金资助课题!(39670650);; 卫生部科学基金
【CateGory Index】: R373.1
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