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《Chinese Journal of Control of Endemic Disenaces》 2001-01
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The role of free radical and oxidative stress in the development of bone lesion in fluorosis

Liu Xiaoqiu, Zhang Xiuyun, Li Guangsheng (Institute of Bioengineering, Norman Bethune University of Medical Sciences, Changchun 130021)  
In fluoride-feeding experiment, the free radical metabolism indices were observed. The anti oxidant enzymes such as Cu, Zn, SOD and GSH-Px activities of experimental animals has no obvious difference from those of control animals, serum LPO level ill high-level fluoride group has no obvious difference from that of control animals. But serum LPO level in moderate dosage fluoride group become lowered. Bone free-radical signals were measured using electronic spin resonance(ESR) Method The free-radical signals of both moderate dosage and high dosage fluoride group were both much higher than those of control group. Pathogenesis of fluorosis is related with free radical metabolism. It has been shown the shortage of definite relationship between free radical indices and bone pathological change from the experiment results. We still do not get the conclusions that free radical participates in the mechanism of pathological change due to skeletal fluoride-poisoning.
【Fund】: 国家自然科学基金资助!项目批准号:39730390
【CateGory Index】: R599
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