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《Chinese Journal of Control of Endemic Disenaces》 2002-01
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The effect of oxidative stress on myocardial injury induced by CVB3m in Se and VE deficient mice

GUO Ling,ZHONG Xue-kuan,ZHOU Ling-wang,et al (Keshan Disease Institute,Harbin Medical University,Harbin 150086)  
Objective To study the effect of oxidative stress on myocardial injury induced by CVB3m in Se and VE deficent mice.Methods Feeding the 7-day-old Kunming mice with both Se and VE deficient composite feed for 4 weeks,then inoculating them intraperitoneally with CVB3m,1 week later,killing them by cervical dislocation.The myocardial lesions were observed under light microscope and the activity of GSH-Px of whole blood and the content of LPO in liver were measured.Results Contrasted with the mice fed normally,the mice fed with composite feed demonstrated severe lesions and high morbidity in heart,low GSH-Px activity in blood and high LPO contenti in liver after virus infection.Conclusion Oxidative stress played an important role in myocardial injury induced by CVB3m infection.
【Fund】: 国家自然科学基金资助项目 (39670 650 );; 卫生部科学研究基金 (96 - 1 - 3)
【CateGory Index】: R542.3
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