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《Chinese Journal of Control of Endemic Disenaces》 2002-02
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The study of clinical of Ⅱstage on treatment endemic skeletal fluorosis by using Fenbid

HUANG Chang-qing,FENG Zhong-bin,X U Hong-wei,et al(The first Institute of Prevention and Treatment on Endemic Diseases of Jilin Province,Baicheng 137000,Chin a)  
Objective According to state of prevention,tr eatment of fluorosis,we search for t he medicine of treatment joint harm of endemic skeletal fluorosis.Methods In alterd water or no disease area ,we selected 100patients which have sym p-tom and sign of endemic skeletal fluorosis using Fenbid 300mg,po,bid as t reatment group,at the same time,using Congrong tablet1.2g,po,bid as control group.We emp loyed"guide principle of the clinical stud y of new drug(Western medicine)"and combined clinical manifestation of endemic s keletal fluorosis observation and e valuated its effect.We observed total curative effect of two kinds of medicines,time of taking effect,side effect and the patients re action of adaplability on medicines.Results The effective rate was 100%in Fenbid group,and the effective rate was 86.49%in Congron g tablet group(P0.005).The time of taking ef-fect was during 1w and the rate of side effect was 20.00%in Fenbid group.The time of taking effect was during 7~15d and the rate of the side effect was 35.14%in C ongrong tablet group.The patience o n medicine of the patients of two grou p were fine.Conclusions Fenbid is effection medicine on trea ting endemic skeletal fluorosis and its effection was better than Congro ng tablet.[
【Fund】: 白城市科委资助项目
【CateGory Index】: R599.9
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