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《Chinese Journal of Control of Endemic Disease》 2005-03
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Study of fluoride on oxidative damage in primary cultured rat hepatocytes

GUO Xiao-ying, SUN Gui-fan(School of Public Health, China Medical University, Liaoning, Shenyang 110001)  
Objective To study the oxidative damage after fluoride exposure in primary cultured rat hepatocytes. Methods Hepatocytes were isolated by half-in situ perfusion method and cultured with various concentrations of sodium fluoride for 24 hours. MTT assays were performed to test cell viability. Meanwhile the activities of ALT, AST and content of MDA were determined. Results Fluoride was toxic to rat hepatocytes. The cell viability decreased. The activities of ALT, AST and the content of MDA increased. Conclusions Oxidative damage induced by lipid peroxidation was the main reason of the cytotoxicity of rat hepatocytes.
【CateGory Index】: R599
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