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《Chinese Journal of Control of Endemic Disease》 2005-06
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A Single cell gel electrophoresis study on DNA damage induced by arsenic,fluoride and their combination in cultured human lymphocytes

ZHENG Yu-jian,ZHANG Jie YAN Ling(Xinjiang Medical University,Urumqi 830054)  
Objective To observe the features of DNA damage induced by arxenic,fluoride and their combination in cultured Human Lymphocytes.Methods The single cell gel electrophoresis(SCGE) was used to measure the DNA damage of cells treated with sodium arsenite and/or sodium fluoried for 24 hours repectively.Results It is shown that sodium arsemite and sodium fluoride has a remarkable damage effect on the DNA of human lymphocytes with the concemtration of 0.1 μmol/Land 10 μmol/L respectively(P0.01).Conclusions Both arsenic and fluoride have damage effect on the DNA of human lymphocytes with lower dose and the interaction in the combination group was froup was found in this test.
【Fund】: 2004年教育部博士点专项科研基金项目
【CateGory Index】: R599
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1 Chang Qing, Li Zicheng. Department of Histology & Embryology,Medical College of Jinan University, Guangzhou 510632;Study of toxic effect of fluoride on reproduction of female mice and development of their offsprings[J];Guangdong Medical Journal;2002-04
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1 LIU Jie,LIU Wen-mei (Health Care Center for Women and Children of Kunming,Kunming Yunnan 650034,China);Fluorine and Health[J];Journal of Kunming Medical University;2009-S1
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