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《Chinese Journal of Control of Endemic Diseases》 2008-06
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Effect of different concentrations of iodine on CK19~+ thymic epithelial cells

XU Ya-ke,LIU Hao,ZHENG Li-na,et al(Department of Histology and Embryology,Tianjin Medical University,Tianjin 300070,China)  
Objective To study the changes of CK19+ thymic epithelial cells after intake of different concentrations of Potassium iodine(KI).Methods Female Wistar rats,1 month after stopping lactation,were divided randomly into 5 groups by giving various concentrations of KI:the lowest iodine(L1),the lower iodine(L2),low iodine(L3),normal iodine(NI),high iodine(HI).After three months,the rats mated with male rats fed with normal-iodine diet.On the 16th day of pregnancy,we measure thyroid hormones in serum,and observe volume density(Vv)and numerical density on area(NA)of thymus CK19+ thymic epithelial cells.Results Compared with normal group,T4 decreased dramatically,Volume density(Vv)and numerical density on area(NA)of thymus CK19+ epithelial cells also decreased significantly in L1 and L2(P0.05),especially,the decrease in L1 is more dramatic;the decrease in L3 and HI has no statistical significance.Conclusions Long time of abnormal intake of KI(deficiency or overdose)results in decreased thyroid hormone level,thereafter CK19+ thymic epithelial cells decrease and thymus degenerate.And the influence of deficiency of iodide is more dramatic than overdose of iodide.
【Fund】: 国家自然科学基金重点资助项目(30230330)
【CateGory Index】: R151
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