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《Chinese Journal of Control of Endemic Diseases》 2009-01
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Effect of leptin on the induction of experimental autoimmune thyroiditis

GUO Xiao-qin,Wu Xue-run,NIU Xiu-long(Department of Immunology,Medical College of CPAPF,Tianjin 300162,China)  
Objective To study the influence of leptin on the induction of experimental autoimmune thyroiditis(EAT).Methods Female C57BL/6J mice were injected intraperitoneally with rmleptin or PBS starting 3 days before the induction of EAT.Histological severity of thyroid specimens was evaluated.The level of spleen lymphocytes proliferative response and the concentration of the cytokines(IFN-γ and IL-4) in the cell supernatants were measured.The serum levels of TPO-Ab,Tg-Ab and leptin were assayed.Results The serum level of leptin was higher in group treated with rmleptin than other two groups.The EAT group treated with rmleptin developed more severe thyroiditis compared with non-treated EAT group.Between two EAT groups,rmleptin did not alter spleen lymphocyte proliferative responses while rmleptin did increase IFN-γ and reduce IL-4 secretion in the cell supernatants.Meanwhile,high serum levels of TPO-Ab and Tg-Ab were presented in the experimental groups.Conclusion The character of proin flammatory of leptin contributes to the induction of EAT.
【CateGory Index】: R581
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