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《Chinese Journal of Control of Endemic Diseases》 2009-01
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Experimental study of arsenic and the antagonistic action of vitamin E on lipid peroxidation in the organs of mice

WANG Qian,LI Yu-hua,LI Shu-lin,et al (Department of Labor Hygiene and Environmental Health College of Public Health,Xinjiang Medical University,Urumqi 830054)  
Objective To study the influence of arsenic and the antagonistic action of vitamin E on lipid peroxidation in the organs of mice.Methods Kunming mice were divided into nine groups according to the factorial experiment design of two factors and three levels.The mice of different groups were fed with both various amounts of arsenic in drinking water and vitamin E for two months to produce the animal model of subchronic arsenic poisoning.The mice were fed the different dose of arsenic the LD50 and the dose of vitamin E according to the youngsters RDA(recommended dietary allowance).The activity of superoxide dismutase(SOD),glutathione peroxidase(GSH-Px) and the contents of malondiasldehyde(MDA) in the organs of mice were measured by test kit.Results The SOD and GSH-Px contents were lower(P0.05),while the MDA contents were higher(P0.05) in arsenic groups.Correspondingly,the SOD and GSH-Px contents were higher(P0.05),while the MDA contents were lower(P0.05) in the groups added with various dose of vitamin E(abbreviated by Vit E+As).Conclusions Lipid peroxidation(LPO) and the anti-lipid peroxidation might play a vital role in the mechanism of arsenism.There was an interaction between arsenic and vitamin E.Vitamin E has an antagonistic action against the arsenism through mataining the balance of the lipid peroxidation and anti-lipid peroxidation system.
【CateGory Index】: R599;R96
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