Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Control of Endemic Diseases》 2010-04
Add to Favorite Get Latest Update

Effect of iodine deficiency and hypothyroidism on the protein expressions of CaMKⅡ in the entorhinal cortex of pups

HOU-Yi,WEI Wei,DONG-Jing,et al(Department of Occupational and Environmental Health,School of Public Health,China Medical University,Shenyang 110001)  
Objective To observe the effect of iodine deficiency and hypothyroidism on the protein expressions of CaMKⅡ in the entorhinal cortex of pups.Methods Female Wistar rats(n=28) after pregenancy were randomly divided into control group,hypothyroid group and iodine deficient group.According to the dose of PTU in fed water,hypothyroid group was divided into 5ppm group and 15ppm group(7 in each).5 pups from each group were sacrificed and perfused intracardially in PN7,PN14,PN21,PN28 and PN42.Brains were removed,fixed and sectioned coronally.All sections were observed and analysed the protein exression of CaMKⅡ by immunohistochemistry in the entorhinal cortex.Results In PN7,PN14 and PN21,protein levels of CaMKⅡ in the entorhinal cortex in iodine-deficient and 15ppm treatment groups was significantly lower than those of controls(P0.05).In PN28 and PN42,protein levels of CaMKⅡ in the entorhinal cortex in iodine-deficient,5ppm and 15ppm treatment groups were significantly lower than those of controls(P0.05).Conclusions Iodine deficiency and hypothyroidism may decrease the protein expression of CaMKⅡ in the entorhinal cortex of pups.
【Fund】: 国家自然科学基金项目(30500400)
【CateGory Index】: R599
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved