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《Chinese Journal of Control of Endemic Diseases》 2010-04
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Effect of T-2 toxin on the growth of rats' body weight and bone at selenium deficiency conditions

SONG Dai-qin,WANG Zhi-lun,CHEN Jing-hong,et al(Key Laboratory of Environment and Genes Related to Diseases,Ministry of Educatim,Emphasis Laboratory of Trace Element and Endemic Disease of Ministry of Public Health,Xi'an 710061)  
Objective From rat with KBD in order to investigate the effects of T-2 toxin at the low selenium conditions.Methods All SD rats were randomly divided into two groups and keeping for one month.When the low-selenium status of rats were determined,they were randomly divided into six groups,control group included.Rats'body weight was measured by automatic weighting scale,and the length of right tibia and the middle frontal diameter measured by vernier caliper.Results Low-Se,T-2 toxin and its combined effects affect the growth of body weight and bone growth.The low selenium group's weight grew slowly in the process of keeping low-Se and compared with the conventional group,there were significant difference(P0.05);compared with the conventional weight,the interventional group with low selenium or T-2 toxin were significantly different(P0.05),particularly the low-Se + high T-2 group's weight were the lowest;compared with the conventional and low-selenium group,the length of right tibia and the middle frontal diameter in low-selenium+ high T-2 group grew slowly,and there were differences(P0.05).Conclusions Long-term selenium deficiency or the combined effects of selenium deficiency and T-2 toxin can affect the growth of body weight and bone,especially the high T-2 toxin had more serious effects in the acute phase of low selenium.
【Fund】: 国家自然科学基金重点项目《大骨节病病因及发病机制研究》(编号:30630058)
【CateGory Index】: R684.1
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