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《Chinese Journal of Control of Endemic Diseases》 2012-06
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Effects of cerebellar development and the expression of CaMKⅡ in the cerebellum of iodine deficient and hypothyroid pup rats

SHAN Liang,DONG Jing,WANG Yi,GONG Jian,LI Jin-yan,CHEN Jie Department of Occupational Health and Environmental Health,School of Public Health, China Medical University,Shenyang 110001,China  
Objective We have tested whether congenital iodine deficiency and hypothyroidism could regulate expression of CaMKⅡin pup cerebellum cortex,and impair functional lesion in pup cerebellum.Methods Female Wistar rats(n=28) after pregnancy were randomly divided into four groups: control group,iodine deficient group,hypothyroid-1 group(5 ppm) and hypothyroid-2 group(15 ppm).The control group was fed a normal diet during the experiment.The iodine deficient group was fed an iodine-deficient diet.The hypothyroid-1 group was fed a normal diet and had 5 ppm PTU-added water and the hypothyroid-2 group had 15 ppm PTU-added water.All the groups were from GD6 through to postnatal day(PN) 28.On PN7,PN14,PN21,PN28,pups in each group the part of the cerebellum were separated from the brain for protein detection by Nissl's staining and CaMKⅡimmunohistochemistry.Results On PN14,PN21,PN28 and PN42,Nissl's body expression in 5 ppm,15 ppm and iodine-deficient groups were significantly lower than those of controls(P0.05);CaMKⅡexpression in 15 ppm and iodine-deficient groups were significantly lower than those of controls(P0.05).Conclusion Iodine deficiency and hypothyroidism during a period of brain development changed cerebellar morphology and affected the expression of CaMKⅡ.The changes could impair synaptic plasticity,affect the formation of normal neural circuit,and resulted in cerebellar development disturbance.
【Fund】: 国家自然科学基金资助课题(30800896)
【CateGory Index】: R581.2
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