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《Chinese Journal of Control of Endemic Diseases》 2013-05
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Impact of AQP7 expression level on arsenic content in cardiac tissue of mice

WU Jun-xia;WANG Yi-jun;CHEN Zhi-fei;ZHANG Xuan;XIANG Quan-yong;WANG Xiao-ke;CHEN Gang;WANG Chun;Occupational Medicine and Environmental Toxicology Teaching and Research Office of Public Health Department of Natong University;  
Objective To investigate if the change of the expression level of AQP7 would have an impact on the arsenic content in cardiac tissue of mice when they were exposed to arsenite.Methods Forty-eight male ICR mice were randomly divided into 4 groups: insulin and arsenic group,saline and arsenic group,pioglitazone and arsenic group and corn oil and arsenic group,with 12 mice in each group.The mice in insulin and arsenic group were given insulin via intraperitoneal injection(0.30 ~ 0.5) IU / d,and those in the control group were given an equal volume of saline.The mice in pioglitazone and arsenic group were given pioglitazone by intraperitoneal injection of 4mg / kg / d,and those in the control group were given the same volume of corn oil.After 4 weeks,all mice were given 0.4mg / kg arsenic trioxide by tail intravenous injection.The mice sacrificed 15 minutes later,and then the heart tissues were taken out for arsenic detection.Arsenic contents were determined by atomic fluorescence spectrum.The expression level of AQP7 was detected by reverse transcription-polymerase chain reaction(RT-PCR).Results The arsenic content in cardiac tissue significantly decreased in insulin and arsenic group {(3517.37 ± 562.29) ng / g} when compare with those in the control group {(4164.26 ± 289.52) ng / g}.The results of RT-PCR showed that the expression level of AQP7 in cardiac tissue significantly decreased in insulin and arsenic group(P = 0.009);The arsenic content in cardiac tissue increased in pioglitazone and arsenic group {(4249.20 ± 748.22) ng / g} when compare with those in the control group {(4065.72 ± 402.22) ng / g},however,the difference was not statistically significant(P = 0.651).The expression level of AQP7 in cardiac tissue in pioglitazone and arsenic group slightly increased,and the difference was not statistically significant(P = 0.053).Conclusion Trivalent arsenic may was transported into cardiac tissue of mice by AQP7.
【Fund】: 江苏省高校自然科学基金(08KJD330002);; 南通市应用研究计划(K2010007)
【CateGory Index】: R114
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