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《Chinese Journal of Control of Endemic Diseases》 2014-01
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Study of the effects of different iodine levels on morphological changes of thyroid and pregnancy outcomes in pregnant rats

LIU Li-xiang;SHEN Hong-mei;DONG Rui-qiang;WANG Xue-jiao;WAN Si-yuan;Iodine Deficiency Disorders Institute,Chinese Center for Endemic Disease ControlHarbin Medical Uniuersity;  
Objective To understand morphological changes of thyroid and pregnancy outcome in rats with different iodine intake. Methods Select 180 Wistar rats( 150 famale and 33 male),who weighed between 80 to 100 g,150 female rats were randomly divided into five groups according to their body weights,every group including 30 rats. Animals in the low iodine groups( LI 1 and LI 2) were fed with low-iodine diet and drank deionized water which contained potassium iodate,the dose was 0,5 μg / L. The rats of adequate( NI) and high iodine group( HI 1 and HI 2) were fed with normal diet, they also drank deionized water, which the dose of contained potassium iodate were 50,3 000,10 000 μg / L. The rats mated after fed for 3 months,then the rats were respectively sacrificed at the first trimester( 5±2 days), the second trimester( 12 ±2 days),and the third trimester( 17 ±2 days) to observe pregnancy outcome and their maternal pathological changes of thyroid by light microscope. Results ①Compared with the NI group, the thyroid absolute quality and relative quality of LI 1 and LI 2 groups increased significantly( P 0. 01 or P 0. 05),and the differences were statistically significant. ② Observed under light microscope, the thyroid of low iodine group showed a typical follicular hyperplasia goiter,the follicular epithelial cells of high iodine group gradually become thallus,the nuclear become shuttle,the cavity of follicle gradually spread compared with control group. ③In the second trimester of pregnancy, the fetal death rate of two LI groups( 39. 88%,22. 22%) were significantly higher than that of NI group( 5. 52%, P 0. 01); In the third trimester, the fetal death rate of LI and HI groups( 42. 96%,32. 05%,16. 13%,13. 04%) were significantly higher than that of NI group( 4. 29%, P 0. 01or P 0. 05). Compared with the adequate group, low iodine and high iodine intake resulted in an increased rate of decreased number of live fetuses at the third trimester. Conclusions Long-term intake of an excess of iodine in rats could have a certain impact of embryonic development.
【Fund】: 国家自然科学基金(81273012)
【CateGory Index】: R153.1;R714.2
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