Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Control of Endemic Diseases》 2014-01
Add to Favorite Get Latest Update

Study of the effects of different iodine levels on morphological changes of thyroid and pregnancy outcomes in pregnant rats

LIU Li-xiang;SHEN Hong-mei;DONG Rui-qiang;WANG Xue-jiao;WAN Si-yuan;Iodine Deficiency Disorders Institute,Chinese Center for Endemic Disease ControlHarbin Medical Uniuersity;  
Objective To understand morphological changes of thyroid and pregnancy outcome in rats with different iodine intake. Methods Select 180 Wistar rats( 150 famale and 33 male),who weighed between 80 to 100 g,150 female rats were randomly divided into five groups according to their body weights,every group including 30 rats. Animals in the low iodine groups( LI 1 and LI 2) were fed with low-iodine diet and drank deionized water which contained potassium iodate,the dose was 0,5 μg / L. The rats of adequate( NI) and high iodine group( HI 1 and HI 2) were fed with normal diet, they also drank deionized water, which the dose of contained potassium iodate were 50,3 000,10 000 μg / L. The rats mated after fed for 3 months,then the rats were respectively sacrificed at the first trimester( 5±2 days), the second trimester( 12 ±2 days),and the third trimester( 17 ±2 days) to observe pregnancy outcome and their maternal pathological changes of thyroid by light microscope. Results ①Compared with the NI group, the thyroid absolute quality and relative quality of LI 1 and LI 2 groups increased significantly( P 0. 01 or P 0. 05),and the differences were statistically significant. ② Observed under light microscope, the thyroid of low iodine group showed a typical follicular hyperplasia goiter,the follicular epithelial cells of high iodine group gradually become thallus,the nuclear become shuttle,the cavity of follicle gradually spread compared with control group. ③In the second trimester of pregnancy, the fetal death rate of two LI groups( 39. 88%,22. 22%) were significantly higher than that of NI group( 5. 52%, P 0. 01); In the third trimester, the fetal death rate of LI and HI groups( 42. 96%,32. 05%,16. 13%,13. 04%) were significantly higher than that of NI group( 4. 29%, P 0. 01or P 0. 05). Compared with the adequate group, low iodine and high iodine intake resulted in an increased rate of decreased number of live fetuses at the third trimester. Conclusions Long-term intake of an excess of iodine in rats could have a certain impact of embryonic development.
【Fund】: 国家自然科学基金(81273012)
【CateGory Index】: R153.1;R714.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 3 Hits
1 YANG Xue-feng,GUO Huai-lan,XU Jian,HOU Xiao-hui,CHEN Xiao-yi,Sun Xiu-fa(Department of Nutrition and Food Hygiene,Tongji Medical College,School of Public Health, Huazhong University of Science and Technology,Wuhan Hubei 430030,China);Effects of different levels of excessive iodine intake on the embryo development in mice[J];Journal of Toxicology;2006-05
2 SANG Zhong-na,ZHANG Shu-fen1,WEI Wei,ZHANG Gui-qin,ZHAO Na,ZHANG Wan-qi(College of Public Health,Tianjin Medical University,Tianjin 300070;1Obstetrics and Gynecology Hospical in Haixing Country,Cangzhou City,Haixing 061200,China);EFFECTS OF EXCESS IODINE INTAKE ON MATERNAL THYROID FUNCTION AND PREGNANCY OUTCOMES[J];Acta Nutrimenta Sinica;2011-05
3 LI Ying hua,ZHU Hui min,DONG Shao xia,et al (Department of Environment Hygiene.He Bei Medical University,Shi Jia Zhuang 050017,China) [;Effects of high iodine on embryo and filial generation in mice[J];CHINESE JOURANL OF CNDEMIOLOGY;2000-03
Chinese Journal Full-text Database 10 Hits
1 Zeng Xiaoqing; Li Shouren; Zhou Shi, et al(Affliated Hospital of Guiyang Medical College, Guiyang 550004);Subclinical Types of Iodine Deficiency Disorders[J];ENDEMIC DISEASES BULLETIN (CHINA);1997-03
2 GAO Xiao Cai 1, LI Sheng Li 2, ZHANG Fu Chang 1 1Appliance Psychology and Cognitive Science Institute, Northwest University, Xi'an 710069, China, 2Department of Otolaryngology, Second Clinical Hospital of Xi'an Medical University, China;Psychomotor function features of mental retarded children with audition handicap in iodine deficiency region[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;2000-03
3 Liu Shoujun, et al Chinese Research Centre for Endemic Disease Control, Harbin;GOITRE RATE AT ULTRASONIC LEVEL OF 10- YEAR-OLD CHILDREN IN HARBIN CITY[J];Chinese Journal of Control of Endemic Disease;1994-06
4 Chen Haomin Henan Provincial Institute for Endemic Diseases Control and Research,Zheng zhou;DDST RESULTS AND ANALYSIS OF 397 CHILDREN IN IDD AREA[J];Chinese Journal of Control of Endemic Disease;1996-01
6 Teng Ruitao, Cui Biao, Wang Jianhui, et al (Liao ning Endemic Disease Control Institute, Shenyang 110005);Audition state of children who was born after universal ioldized salt in IDD regions[J];Chinese Journal of Control of Endemic Disenaces;2000-06
7 WANG Hai - ming, BIAN Jian - chao, YANG Xiao - xia ( Shandong Institute for Prevention and Treatment of Endemic Disease, Jinan 250014, China);Effects of zinc on the growth and the thyroid function in rats with iodine deficiency[J];Chinese Journal of Control of Endemic Disease;2004-01
8 HE Ying-xia,ZHAO Jin-kou,ZHANG Qing-lan,et al (Jiangsu Provincial Center for Disease Prevention and Control,Nanjing 210009,China);Follow-up on urinary iodine level of schoolchildren after universal salt iodization in Jiangsu Province[J];Chinese Journal of Control of Endemic Disease;2004-04
9 LIU Hua-lei,ZHAO Juan,CHEN Chong-yi (Department of Occupational Health and Environmental Health,Hebei Medical University,Shijiazhuang 050017);Studies of the effects of Tyrosine on goiter pathogenesis in mice[J];Chinese Journal of Control of Endemic Disease;2004-05
10 XIE Wen-qin,LIU Shou-jun,YU Jun,et al (Center for Disease Control and Prevention of Anhui,Hefei 230061);The effects of potassium iodate and potassium iodide on morphology and function of thyroid in mice[J];Chinese Journal of Control of Endemic Disease;2004-06
China Proceedings of conference Full-text Database 1 Hits
1 SANG Zhong-na GUO Xiao-wei SHEN Jun LIU Jia-yu College of Publics Health,Tianjin Medical University,Tianjin 300070,China;NUTRITION SURVEY OF CHILDREN AGED 7-10 YEARS OLD IN SHANDONG EXCESSIVE IODINE INTAKE AREA[A];[C];2007
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 Gao Qiuju, et al Hebei University of Medical Sciences;THE EXPERIMENTAL STUDY OF HIGH IODINE ON EMBRYOTOXICITY[J];Chinese Journal of Control of Endemic Disease;1998-05
2 YAN Yu qin, CHEN Zu pei (Institute of Endocrinology, Tianjin Medical University, Tianjin 300070, China);Correct or standardized application of the biological indicator--Urinary Iodine[J];Chinese Jouranl of Endemiology;2002-06
3 GUAN Haixia *, TENG Weiping, CUI Bingyuan, et al. *Department of Endocrinology, The First Hospital, China Medical University, Shenyang 110001,China;An epidemiological survey of thyroid disorders in an area with high iodine content in water supply[J];Chinese Journal of Internal Medicine;2001-09
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved