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《Chinese Journal of Control of Endemic Diseases》 2014-S1
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Low-molecular-weight heparin plus aspirin compared with aspirin alone for the treatment of acute ischaemic stroke with large artery atherosclerotic stenosis disease

ZHANG Chun-peng;CHEN Yi-fei;ZHANG Hai-yan;  
Objective To compare the efficacy of low-molecular-weight heparin(LMWH)plus aspirin with aspirin alone in the treatment of acute ischemic stroke with large artery occlusive disease.Methods A total of 150 patients with both acute ischemic stroke and large artery atherosclerotic stenosis disease were randomly assigned to combination therapy group(LMWH 5000IU,subcutaneously q12 hplus aspirin 200 mg,once daily)or monotherapy group(aspirin 200mg,once daily).NIH Stroke Scale(NIHSS)and modified Rankin Scale(mRS)scores were checked before and after10 days and 3 months of drug administration.Hemorrhagic and other adverse events were also observed.Results The NIHSS scores after 10 days were lower(P=0.002)while the frequency of the favorable functional status of mRS 0-1 at month 3 was significantly higher(P=0.041) in the combination therapy group than in the monotherapy group.No severe hemorrhagic complications occurred during treatment in the two groups.Conclusion Patients treated with LMWH plus aspirin during the acute phase of large artery atherosclerotic stenosis ischemic stroke are more efficient than aspirin alone,and have more favorable functional outcome.Combination therapy with LMWH and aspirin does not increase incidence of severe hemorrhage events.
【CateGory Index】: R743.33
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