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《Chinese Journal of Control of Endemic Diseases》 2014-S1
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The Study of Clinical Efficacy and Safety of Statinsin Treatment of Patients at Age of 80 Years or Elder

GUO Shao-min;  
Objective:Discusses the application of 80 year old patients or higher statin lipid-lowering effect and safety.Methods Choose our 80 year old patients with dyslipidemia or 96 people,randomly assigned for atorvastatin group(50)and simvastatin group(46)treatment for 1 year.Observation indexes such as liver and kidney function,blood lipids index.Results Simvastatin group total effective rate was 85.12%,atorvastatin group total effective rate was 95.15%,the comparison between the two groups was statistically difference(P0.05).In the two groups before and after treatment comparison of total cholesterol(CHO),triglycerides(TG)and low density lipoprotein(LDL-C),high density lipoprotein(HDL-C),the difference had statistical significance(P0.05).And alanine aminotransferase(ALT),aspertate aminotransferase(AST),creatine kinase(CK),creatinine(Cr),fasting plasma glucose(GLU),there was no statistically significant difference(P0.05).Conclusion Statins for patients,a 80 year old is safe and effective,or atorvastatin has better security advantages.
【CateGory Index】: R589.2
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【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 LI Guangxin YU Mingmin Huoshan County Hospital of Traditional Chinese Medicine in Anhui Province,Huoshan 237200,China;Efficacy and safety analysis of atorvastatin lipid-lowering therapy for acute coronary syndromes[J];China Medicine and Pharmacy;2013-03
2 YAN Wen-fei;PANG Ming-jie;The First Department of Internal Medicine,Yunnan Provincial Geriatric Hospital;Dept.of Cardiology,The 1st People's Hospital of Yunnan Provina;;The Study of Clinical Efficacy and Safety of Atorvastatin in Treatment of Elderly Patients with Hyperlipidemia[J];Journal of Kunming Medical University;2013-07
3 GENG Hui;LIU Meilin;Department of Geriatrics,First Hospital,Peking University;;Update on the management of dyslipidemia[J];Journal of Clinical Cardiology;2014-02
4 CUI Wei;Department of Cardiology,the Second Hospital of Hebei Medical University,the Institute of Cardiocerebrovascular Disease of Hebei Province;;Statin administration and kidney diseases[J];Clinical Focus;2014-01
5 GENG Xue;ZHANG Kai;CUI Wei;Department of Cardiology,the Second Hospital of Hebei Medical University;Department of Cardiology,Handan Central Hospital;;Effect of high-dose pre-operative statin therapy on contrast-induced nephropathy after angiography:a meta-analysis[J];Clinical Focus;2014-01
6 YE Piao;TAN Ning;LIU Yong;LIU Yuan-hui;HE Yi-ting;RAN Peng;LI Hua-long;JIANG Lei;Department of Cardiology,Guangdong General Hospital;;Impact for Different Dose of Atorvastatin on Contrast-induced Nephropathy in Patients With High Level of hs-CRP After Percutaneous Coronary Intervention[J];Chinese Circulation Journal;2014-04
7 LU Renrong;MA Jie;YU Xin;LIN Meiming;Department of Cardiology,affiliated Sanming First Hospital of Fujian Medical University;;Efficacy of different time of therapy with atorvastatin attenuated contrast induced renal function damage[J];Journal of Cardiovascular and Pulmonary Diseases;2014-03
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