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Autophagy Signaling Adaptor Protein P62 in Malignant Tumors

Cui Chao;The first hospital of Harbin;  
Adaptor proteins praticpate in selective attophagy,which is critical for cellular detoxification and stress relief.However,new evidence supports an autophagy-independent key role of the adaptor P62(encoded by the gene sqstm1)in signaling functions central to tumor initation in the epithelium and suppression of tumor progression int the stroma.
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