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《Progress in Veterinary Medicine》 1997-01
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Study on Sterigmatocystin Poisoning in Mules

Sha Yongbo, Cao Guangrong,Li Shaojin, Kong Fangling(Animal Quarantine Station ,Yin Chuan ,China)  
Apale yellow needle—like crystal was extracted from the cultured materials of Aspergillus versicolor and A. nidulans and identified by organic spectrums to be sterigmatocystin(ST). The ST content in the crude extracts was measured by ultraviolet TLC scanner. 4mg/kg of ST was orally administrated to each of the four mules daily for the first 10 days, 8mg/kg for following 26 days. on day 17 of the administration, the animals showed toxic symptoms;on day 36 of the exepriments, 3 of the 4 animals were died. The toxic symptoms and necropsy changes were very similar to the "yellow liver disease" in two counties of Yan Chi and Lin Wu of Ning Xia. The regular blood examinations showed that the number of neutrophlis was incraesed and lymphocytes decraesed. The blood biochemcal examinations indicated that the activities of serum GOT, GPT, SDH, AKP, LDH were elevated and the concentration of BUN ineraesed. The concentration of total protein, albumen and globin in serum were declined. The necropsy showed a yellow colour in subcutaneous tissues and internal organs accompanying with intensive hemorrhage. Histopathological findings characterised by the vaculation of liver, renal tubular epithelia and cerebrum cells. Thus,it is believed that "yellow liver dissase", having been reported for many years in Ning Xia, is mainly caused by ST poisoning.
【CateGory Index】: S858.22
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