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《Progress in Veterinary Medicine》 2012-01
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Therapeutic Effect of Taurine on Streptozotocin-Induced Ⅰ-Type Diabetes Mellitus in Rats

YANG Zuo-feng1,DONG Na2,LI Yang2,FU Li2,JIAO Yang2,MU Dan-yang2, XU Yan-long2,LI Bing2,LIU Zhi-xiang2(1.Liaoning Center for Animal Disease Control and Prevention,Shenyang,Liaoning,110164,China; 2.Animal Medicine and Feed Supervision Institute of Shenyang,Shenyang,Liaoning,110031,China)  
To explore the effect of taurine on blood glucose,lipid metabolism,and the function of islet β cells in streptozotocin-induced diabetes mellitus rats.Diabetes mellitus rats were treated with taurine everyday,when observing their body weight and blood glucose during the 70d.The rats were killed at the 8th week of treatment,then the contents of the follow blood indexes in the diabetes mellitus rats were measured: fasting blood glucose,C-peptide(C-P),glucagon(Glu),superoxide dismutase(SOD),glutathione GSH peroxidase(GSH-Px),malondialdehyde(MDA),total antioxidant capacity(T-AOC),total cholesterol(TC),triglyceride(TG),high density lipoprotein(HDL).Histological lesions were observed after HE stain.Apoptosis of β-cells were analyzed by way of TUNEL in situ end-labeling.At the same time,the expression of Fas,bax and bcl-2 in islet cells were observed by the way of immunohistochemistry.The results indicated that:blood glucose,glucagon levels,TG,TC and MDA of Tau group decreased,body weight,C-peptide levels,SOD,GSH-Px,T-AOC,HDL of Tau group increased;In Tau group,the structure of islet was integrity,the number of apoptosis and expression of Bcl-2 were low,the expression of Bax and Fas were high.It has significant differences(P 0.05) compared with diabetes mellitus model group.Taurine has a protective effect on blood glucose,lipid metabolism,and pancreatic islet cells.
【CateGory Index】: R587.1
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