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《Progress in Veterinary Medicine》 2017-02
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Genetic Correlation and Immunogenicity Analysis of S,M,N Genes of Porcine Epidemic Diarrhea Virus

YI Xin-jian;LIU Zhun;ZHANG Cui-cui;ZANG Chuan-jiao;XU Jian;CHEN Shen-miao;Shandong Binzhou Wohua Biological Engineering Company Limited,Engineering Laboratory of Animal Pathogenic Microorganisms in Shandong Province;  
To carry out the genetic variation and diversity of antigenic sites between CV777 vaccine strain and epidemic strain of porcine epidemic diarrhoea virus,RT-PCR was used to clone the S,M and N genes of PEDV CV777 vaccine strain and JS2016 strain,then the PCR products were sequenced for analyzing the nucleotide sequences and antigenic sites.The nucleotide sequence of CV777 vaccine strain had some variation compared to JS2016 strain,but the homology was higher than 93%.The prediction result of immunogenicity showed that less differences of antigenic sites of S,M and N genes exist between CV777 vaccine strain and JS2016 strain.
【CateGory Index】: S852.651
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