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《Progress in Veterinary Medicine》 2017-02
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Progress on Molecular Mechanism of Bacterial Drug Resistance and Its Effect on Bacterial Virulence

ZHAO Qiu-yun;YUAN Fu-wei;LIU Rui-qi;WANG Wei-wei;XU Yong-ping;ZHANG Wei-min;QING Su-zhu;College of Veterinary Medicine,Northwest A&F University;Henan Muxiang Veterinary Pharmaceutical Limited Liability Company;  
The phenomenon of bacterial drug resistance has become serious gradually because of the selective pressure of antimicrobials.Studies have shown that some molecular mechanisms of bacterial resistance could cause the change of bacterial pathogenicity,which indicated the relativities between the two.In this paper,we summarized the molecular mechanisms of bacterial resistance,introduced the bacterial pathogenic process which includes the molecules closely related to drug resistance,analyzed the effects of bacterial resistance on the changes of bacterial virulence from 4parts containing the bacterial cell wall,membrane,cytoplasm,and chromosome.We hope to find some new methods or breakthrough points to solve the difficult problems of the present serious bacterial resistance and bacterial disease prevention.
【Fund】: 陕西省科技攻关项目(2014K02-05-01);; 陕西省农业财政项目(K332021402)
【CateGory Index】: R446.5
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