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《Progress in Veterinary Medicine》 2017-02
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Advance in Osteoclast Related MicroRNAs

KONG Qi;SUN Zi-qiang;WANG Dong;LIU Wei;SONG Rui-long;GU Jian-hong;LIU Zong-ping;Colleges of Veterinary Medicine,Yangzhou University;Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses;  
MicroRNA,a class of noncoding RNA,has approximately 22 nucleotides and exists in eukaryotic cells widely.It is demonstrated that miRNAs play an important role in physiological prosesses of organism such as growth,development and occurrence of disease.With the deep research,how miRNAs affect bone metabolism is going to be clear.As the unique cell responsible for bone resorption,osteoclast(OC)is an important participator in physiological and pathological processes of bone tissue.The formation and differentiation of osteoclast is regulated by multi factors,such as various miRNAs.miR-21,miR-422 aand miR-148 acan promote the differentiation of OC,while miR-124,miR-155 and miR-503 suppress the formation of OC,some miRNAs can also mediate tumor bone metastasis via OC.Study of these mechanisms will reveal the causes of metabolic bone disease on another level and provide guidance for clinical treatments.This paper reviewed the functions and mechanisms of miRNAs in the formation and differentiation of osteoclasts.
【Fund】: 国家自然科学基金项目(31672620 31372495 31302154);; 江苏省高校自然科学基金项目(13KJB230002);; 高等学校博士学科点专项科研基金项目(20133250120002);; 江苏高校优势学科建设工程资助项目
【CateGory Index】: R681
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