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《Progress in Veterinary Medicine》 2017-02
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CYP3A Enzyme and Its Potential Significance in Metabolic Properties of Bactrian Camels

YUE Wei-dong;SAN Ren;HASI Su-rong;College of Veterinary Medicine,Inner Mongolia Agricultural University;Key Laboratory of Clinical Diagnosis and Treatment Technology in Animal Disease,Ministry of Agriculture;  
Cytochrome P4503A(cytochrome P4503 A,CYP3A)is the most important functional form of the CYP enzyme superfamily in animal liver,account for 30% of the total hepatic CYP enzymes,and responsible for biotrans formation of 45%-60% commonly used drugs in vivo.The systematic study on various CYP3 Aenzymes was carried out,including the molecular structure,genetic diversity,in vivo activity of CYP3 A,and the influencing factors.We reviewed the biological characteristics of the CYP3 Asubfamily,the significance of CYP3 Aenzyme in the metabolism of endogenous compounds and xenobiotics,CYP3 Agene expression and regulation,induction and inhibition of the CYP3 Aenzyme,and research achievements of Bactrian camel CYP3 Aenzyme in this article.
【Fund】: 国家自然科学基金项目(31260623)
【CateGory Index】: S852.2
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