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《Progress in Veterinary Medicine》 2017-06
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Effect of Different Load Exercises on Skeletal Muscle Cell Apoptosis in Mice

CEN Ren-jun;HUA Qi-kai;WEI Xue-liang;ZHANG Wen-zhen;College of Physical Education of Guangxi University;The First Affiliated Hospital of Guangxi Medical University;Stomatological Hospital Affiliated to Guangxi Medical University;  
To investigate the effect of different load exercise on the apoptosis of skeletal muscle cells and the expression of Akt and mTOR protein in mice,30 mice were divided into three groups,which were control group(C),high intensity exercise group(H),and exhaustive exercise group(G).The control group did not exercise training.High intensity exercise group(H)gave 25m/min exercise training.Exhaustive exercise group(G)was given 10m/min exercise training to exhaustion.After 6weeks of exercise,the gastrocnemius muscle was taken to detect the apoptosis by TUNEL.Detection of Bcl-2,Bax,mTOR,Akt protein levels in the organization by Western blot.Content of malondialdehyde(MDA)was detected by biuret method.SOD activity was detected by xanthine oxidase method.The apoptosis indexes of high intensity exercise group(H)and exhaustion group(G)were higher than that of control group(C).The apoptosis index of high intensity exercise group(H)was higher than that of exhaustive group(G).High intensity exercise group(H)and exhaustion group(G)Bax protein levels were higher than the control group(C).High intensity exercise group(H)Bax level was higher than the exhaustive group(G).The levels of Bcl-2,mTOR and p-Akt in the high intensity exercise group(H)and the exhaustion group(G)were lower than those in the control group(C).High intensity exercise group(H)Bcl-2,mTOR,p-Akt protein levels were lower than the exhaustive group(G).High intensity exercise group(H)and(G)Akt protein levels had no significant change compared with the control group(C).High intensity exercise group(H)and exhaustion group(G)MDA contents were higher than the control group(C).The content of MDA in high intensity exercise group(H)was higher than that in exhaustion group(G).SOD activities in high intensity exercise group(H)and exhaustion group(G)were lower than that in the control group(C).High intensity exercise group(H)SOD activity was lower than the exhaustive group(G).High intensity exercise and exhaustive exercise could induce the apoptosis of skeletal muscle cells,and high intensity exercise exercise is more likely to cause apoptosis in skeletal muscle.
【CateGory Index】: G804.2;R87
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1 CEN Ren-jun;HUA Qi-kai;WEI Xue-liang;ZHANG Wen-zhen;College of Physical Education of Guangxi University;The First Affiliated Hospital of Guangxi Medical University;Stomatological Hospital Affiliated to Guangxi Medical University;;Effect of Different Load Exercises on Skeletal Muscle Cell Apoptosis in Mice[J];动物医学进展;2017-06
2 KONG Mei;ZHANG Xiang;YE Mei-Ling;ZHANG Xue-Lin;College of Physical Education, Qufu Normal University;;Changes of perimysial junctional plates induced by excessive eccentric training and the effects of acupuncture intervention[J];生理学报;2017-01
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