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《Progress in Veterinary Medicine》 2017-12
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Development of Detection Indices of Noninvasive Lung Function in Rats

LIU Jun-dan;QIU Wen-cai;LI Zi-yuan;LIANG Wei-shen;TANG Lu-ping;HE Yong-ming;Department of Veterinary Medicine,Foshan University;  
The basic data of the rat lung functions were measured by double cavity method,which would provide a reference for the detection of pulmonary function in the rat animal models related to respiratory system diseases.17 items of lung functions in 40(Sprague-Dawley)SD rats were determined by EMKA noninvasive pulmonary function monitoring system,which were tidal volume,TV;expired volume,EV;minute volume,MV;inspiratory time,Ti;expiratory time,Te;peak inspiratory flow,PIF;peak expiratory flow,PEF;relaxtion time,RT;breathing frequency,f;end-inspiratory pause,EIP;end-expiratory pause,EEP;pause,Pau;enhanced pause,Penh;time delay,dT;specific airway resistance,SRaw;specific airway conductance,SGaw and mid-expiratory flow,EF50.The measured values were as follows:TV was 1.01 mL(0.41-2.23),EV 1.01 mL(0.41-2.22),MV 226.02 mL(76-517),Ti 144.17 msec(108-204),Te 172.45 msec(118-265),PIF 11.05 mL/s(4.6-27.1),PEF 10.58 mL/s(3.4-23.9),RT 107.08 msec(76-188),f 196.88 bpm(141-255),EIP 2.72 msec(2-4),EEP 19.956 msec(13-32),Pau 0.63(0.41-0.88),Penh 0.62(0.33-1.06),dT 39.56 msec(4.56-96.38),SRaw 38.53 cmH_2O.s(2.27-83),SGaw 0.078 l/cmH_2O.s(0.01-0.37)and EF 50 9.5 mL/s(3-20).Meanwhile,the results showed that partial indicators of pulmonary functions in rats had significant differences between different periods and gender.Multi-indices of noninvasive lung function in SD rats were measured for the first time,which had irreplacable value for the study of respiratory diseases and the establishment of relevant standards.
【Fund】: 十二五农村领域国家科技计划课题(2011BAD34B00);; 农业部行业科技专项(201003060-09);; 广东省省级科技计划项目(2015A040404048);; 佛山市科技计划项目(佛财工[2015]143)
【CateGory Index】: R-332;R56
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