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《Progress in Veterinary Medicine》 2017-12
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Effects of Kinetin on Pathological Lesions and Aβ Expression in Brain of AD Mouse Model Induced by AlCl_3 and D-galactose Combination Treatment

LIU Dan;WEI Yun-peng;OUYANG Wu-qing;College of Veterinary Medicine,Northwest A&F University;  
The aim of this study was to investigate the neuroprotective effects of kinetin on AD mouse models.The AD mouse models were prepared by AlCl_3 and D-galactose,and at the same time were treated with different concentrations of kinetin.The hippocampal CA3 region was observed by HE staining.Immunohistochemical staining ofβamyloid protein(Aβ)in the cortex and hippocampus was also performed.The results showed that the pyramidal cells in the hippocampal CA3 region of the mice treated with AlCl_3 and Dgalactose had a significant pathological change,but the intervention of kinetin reduced the lesion.At the same time,the distribution of Aβ1-42 in cortex and hippocampus was significantly increased compared with the blank group,but that in kinetin intervention group was significantly decreased.All the results showd kinetin dose-dependent characteristics.These results indicated that kinetin has some positive effects on AD mouse models,and may has the potential to fight AD.
【Fund】: 陕西省重大科技创新专项基金(K332020916)
【CateGory Index】: R-332;R749.16
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