Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Progress in Veterinary Medicine》 2018-05
Add to Favorite Get Latest Update

Study on Safety Pharmacology of Banlian Baidu Oral Liquid

LIANG Wei-shen;LIU Yi-lei;LI Zi-yuan;LIU Jun-dan;QIU Wen-cai;TANG Lu-ping;HE Yong-ming;Department of Veterinary Medicine,Foshan University;  
The paper aimed to research the safety pharmacology of Banlian Baidu oral liquid.The effects of drugs on nervous system were examined by hypnosis test using pentobarbital sodium threshold dose(subthreshold dose),and by general state and voluntary activity test and coordination test in mice.MC4000 noninvasive blood pressure meter and EMKA small animal noninvasive pulmonary function instrument were used to test the function of cardiovascular system and respiratory system and record the related data such as blood pressure,pulse,diastolic pressure,systolic pressure,respiratory rate,tidal volume and other related indicators at different period of time,and then analyze the effects of drugs on the cardiovascular system and respiratory system in rats.The results of hypnotic effects of Banlian Baidu oral liquid on pentobarbital sodium threshold dose(subthreshold dose)showed that sleep duration and the number of sleeping mice in three dose groups had no significant difference compared with the control group.There were no significantly different among the three groups in general status,activity test and functional coordination exercise test in mice.The Banlian Baidu oral liquid had no significant effect on mean arterial pressure,heart rate,respiratory rate and tidal volume in rats.Banlian Baidu oral liquid had no significant effect on the animal's central nervous system,cardiovascular system and respiratory system and it is a safe drug in clinic.
【Fund】: 广东省省级科技计划项目(2015A040404048);; 广东省自然科学基金(2017A030310607);; 广东省高校省级特色创新项目(2016KTSCX149)
【CateGory Index】: S853.74
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved