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《Progress in Veterinary Medicine》 2018-05
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Effects of Piperphentonamine Hydrochloride on QT Intervals of ECG in New Zealand Rabbits

JIANG Li;OU Si-lin;WU Yun;ZHAO Yue;CHEN Zao-mei;CHEN Ke-jun;WU Qing-rong;ZHU Jin-hui;LI Ru-bing;Southern Medical University;Guangzhou General Hospital of Guangzhou Military Command;  
This study aimed to observe the effects of different doses of piperphentonamine hydrochloride(PPTA)on QT intervals in New Zealand rabbits.Forty New Zealand rabbits were randomly divided into 5 groups(n=8):solvent control group(5% glucose),low-(2.5 mg/kg),medium-(10 mg/kg),high-dosage PPTA groups(25 mg/kg)and positive control group(9 mg/kg sotalol).The surface ECG technique was used to record the ECG change of rabbits in the lead II dent way after giving corresponding drugs by Pclab-530 Cbiomedical signal acquisition and processing system.Result showed that 2.5 mg/kg and 10 mg/kg PPTA did not cause QT interval prolongation after administration,25 mg/kg PPTA led to QT interval prolongation slightly within 15 min after injection(P0.05);The influence of PPTA on QT interval mainly happened after drug injection from 0 min to 15 min,45 min later,QT interval returned to normal.Therefore,low-dosage and medium-dosage of PPTA do not cause QT interval prolongation in New Zealand rabbits,with high security,high-dosage of PPTA has a potential risk of arrhythmia,and suggest that when we use the drug in clinic,we should pay more attention to the dose of it to prevent the QT prolongation and arrhythmia.
【Fund】: 军队后勤科研项目(CGZ16C009);; 广州市科技计划项目(201509010012);广州市科技计划项目(201704020173)
【CateGory Index】: R965
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