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《Progress in Veterinary Medicine》 2018-06
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Preliminary Study on Effect of Hsp90AB1 Protein on Rabies Virus Replication

XU Yun-bin;SUN Yu-zhang;LIU Juan;YAN Yan;GAO Xing-hong;LUO Guo;WANG Huan;Key Laboratory of Infectious & Biosafety,Department of Education,Guizhou,Zunyi Medical University;Qingdao Vland Biotech Group Co.Ltd,National Research Center for Animal Health Products;Key Laboratory of Animal Virology of Ministry of Agriculture,Zhejiang University;  
In order to investigate the function of host protein Hsp90AB1 in rabies virus(RABV)replication,the effect of Hsp90AB1 on RABV replication was analyzed preliminarily by using the model of mouse neuroblastoma N2 acells infected with rabies virus(RABV)vaccine strain HEP-Flury.Using RNA interference,it was found that Hsp90AB1 knockdown affected the transcription and expression of viral gene,but did not affect the level of viral anti-genomic RNA and virus infectivity,indicating that RABV replication was affected by Hsp90AB1 at the protein level or at the transcription level.The above results showed preliminarily the effect of Hsp90AB1 on RABV replication,which provided the basic data for further study on the detailed mechanism of Hsp90AB1 during RABV infection.
【Fund】: 国家重点研发计划项目(2016YFD0500402);; 贵州省教育厅资助项目(黔教合KY字[2015]331);贵州省教育厅资助项目(黔教合KY字[2017]185);; 遵义医学院博士科研启动项目(F-812)
【CateGory Index】: S852.65
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