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《Progress in Veterinary Medicine》 2018-06
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Study on Immune Efficacies of A Trivalent Inactivated Vaccine against Newcastle Disease,Infectious Bursal Disease and Avian Influenza(Subtype H9) in Chicks

ZHANG Zhen-hua;LI Lin;JING Xiao-dong;ZHANG Jian-wei;SHEN Jia;SHI Ai-hua;ZHEN Xiao-Lan;JIANG Bei-yu;Institute of Animal Husbandry and Veterinary Medicine,Beijing Academy of Agriculture and Forestry Sciences;  
To evaluate immune efficacy of a trivalent inactivated vaccine against Newcastle disease(ND),infectious bursal disease(IBD)and avian influenza(AI)(subtype H9),the vaccine was administered to SPF chicks and common healthy chicks with maternal antibodies at ages of 1,7,10,14 and 21-day-old.The blood samples of the chicks were collected at 21-28 days after vaccination,then ND haemagglutination inhibition antibody(HIAb),IBD neutralizing antibody(NA)and AI(H9)HIAb were examined,and the virulent IBDV challenge was carried out.The experimental results showed that for SPF chicks vaccinated at ages of 1,7,10,14 and 21-day-old,ND HIAb,IBD NA and AI(H9)HIAb titers were 7.9 to 8.3,13.9 to 15.8 and 8.0 to8.9 log2,respectively,protection rates against IBDV challenge were 100%;that for common healthy birds vaccinated at 1-day-old,ND HIAb,IBD NA and AI(H9)HIAb titers were 5.9,12.1 and 5.6 log2;that for common healthy birds vaccinated at ages of 7,10,14 and 21-day-old,ND HIAb,IBD NA and AI(H9)HIAb titers were 6.1 to 7.0,12.6 to 14.5 and 6.0 to 7.5 log2,the protection rate against IBDV challenge,in common healthy birds vaccinated at 1-day-old was 60%,in common healthy birds vaccinated at ages of 7,10,14 and 21-day-old were 100%.The results confirmed that the immune efficacy in vaccinated SPF chicks was higher than that in the common chicks carrying maternal antibodies,the immune efficacy in vaccinated1-day-old common chicks was significantly lower than that in the other ages of common chicks.In accordance with the trial data,the vaccine is recommended to give to chicks at ages of 7 to 14-day-old.
【Fund】: 北京市农林科学院创新能力建设项目(KJCX20150703 KJCX20161503 KJCX20180111);北京市农林科学院院级科技创新团队项目(JNKYT201602)
【CateGory Index】: S858.31
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