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《Progress in Veterinary Medicine》 2018-06
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Study on Test of Non-invasive Lung and Cardiac Functions in Mice

QIU Wen-cai;LIN Jie-wei;LI Zi-yuan;LIANG Wei-shen;LIU Jun-dan;TANG Lu-ping;HE Yong-ming;Department of Veterinary Medicine,Foshan University;  
The experiment used the methods of double cavity and tail set to measure the basic data of lung and cardiac functions in mice,so as to provide the reference for the study of respiratory diseases and cardiovascular diseases.Enterprisi EMKA noninvasive lung function monitoring system and MC4000 blood pressure analysis system were used to measure 21 indicators of lung and cardiac functions in 100 SPF KM mice.The experimental results showed that systolic blood pressure(SBP)was 131 mmHg±19 mmHg;diastolic blood pressure(DBP)was 119 mmHg±18 mmHg;mean arterial pressure(MAP)was 123 mmHg±18 mmHg;pulse(P)was 716 beats/min±73 beats/min;inspiratory time(Ti)was 96.29 ms±9.93 ms;expiratory time(Te)was 91.80 ms±12.70 ms;peak inspiratory flow(PIF)was 1.88 mL/s±0.31 mL/s;peak expiratory flow(PEF)was 2.36 mL/s±0.32 mL/s;tidal volume(TV)was 0.13 mL±0.02 mL;maximum volume(EV)was 0.13 mL±0.03 mL;rest time(RT)was 52.62 ms±5.97 ms;minute ventilation(MV)was 42.02 mL±6.11 mL;breathing frequency(f)was 323.78 bpm±36.09 bpm;endinspiratory pause breathing(EIP)was 1.79 ms±0.35 ms;end expiratory pause breathing(EEP)was 12.72 ms±2.50 ms;temporary pause(Pau)was 0.75±0.12;bronchoconstriction(Penh)was 0.95±0.17;delay time(dT)was 2.89 ms±1.20 ms;special airway resistance(SRaw)was 2.81 cm±1.18 cm H_2O.s;specific airway conductance(SGaw)was 0.46 L/cm±0.22 L/cm H_2O.s;mid expiratory flow velocity(EF50)was 2.14 mL/s±0.35 mL/s.As the same time,results found that the difference of partial lung function in KM mice was statistically significant in different time points and genders.This experiment for the first time measured a number of indicators in KM mice for noninvasive lung and cardiac functions,which provided basic information for the study on the respiratory system diseases and cardiovascular diseases and the relevant standard formulation.
【Fund】: “十二五”农村领域国家科技计划课题(2011BAD34B00);; 农业部行业科技专项(201003060-09);; 广东省省级科技计划项目(2015A040404048);; 广东省自然科学基金项目(2017A030310607);; 佛山市科技计划项目(佛财工[2015]143);; 广东省高校省级特色创新项目(2016KTSCX149)
【CateGory Index】: R44
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