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《Progress in Veterinary Medicine》 2018-06
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Progress on Regulation Mechanism of Copper Homeostasis in Kidney

LI He;SUN Sheng-yue;HUANG Yuan-long;YANG Wen-yan;YANG Lian-yu;College of Animal Science and Technology,Jilin Agricultural University;Jilin Key Laboratory of Animal Nutrition and Feed Science;  
In the process of mammalian life,it is almost inseparable from the redox properties of copper and iron.Copper is often used as a complementary group in the form of Cu~+ that associated with some related proteins,and the structures of copper-binding proteins play important roles in their biological function.The kidney is the organ of copper excretion.The absorption,storage,release,and transport of copper in the kidney cells are important for copper homeostasis in the kidney.The imbalance of copper homeostasis in the kidneys causes disruption of the mitochondrial structure in the kidneys,and the loss of renal cells leads to impaired renal excretion.With the study of the renal copper transporter and the target cells.this article reviewed the intracellular binding pathways of mitochondria,Golgi,and cytoplasm with copper chaperones and copper transporters,clarified the mechanism of copper transporter(CTR1)expression and the mechanism of redistribution of protein(ATP7A)and protein(ATP7B)under the high level of copper in order to reveal the theoretical basis of the renal copper homeostasis mechanism.
【Fund】: 国家自然科学基金青年科学基金(31302002);; 吉林省自然科学基金(20150101075JC)
【CateGory Index】: S852.2
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