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《Progress in Veterinary Medicine》 2018-06
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Progress on Targeting DNA Sensor Adjuvants

CHEN Jing;TIAN Yuan;BAI Guo-hui;Medical and Biological Research Center,Zunyi Medical College;Key Laboratory of Oral Disease of Higher Schools in Guizhou Province;Affiliated Dental Hospital of Zunyi Medical College;  
The DNA vaccines get into the body,expres in muscle cells,phagocytic cells,and directly or indirectly present to T cells.Recent studies have found that DNA vaccine itself as a pathogen associated molecular pattern is recognized and bound in the cytoplasm of DNA receptor,and activates innate immune responses and adaptive immune response through activation of type I interferon,proinflammatory cytokines,for understanding the immune mechanism of DNA vaccine to improve the immunogenicity of DNA vaccine.This paper summarized the latest research on some DNA receptors and DNA metabolites as the molecular adjuvant mechanism,as well as the experimental study of adjuvants.Therefore,it provided new ideas for developing novel adjuvants with activty,high efficiency,low toxicity,and therapeutic effect,as a target for improving immunination of DNA vaccine.
【Fund】: 国家自然科学基金项目(81560186);; 贵州省科技厅社发攻关项目(黔科合SY字[2013]3043号)
【CateGory Index】: R392
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