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《Progress in Veterinary Medicine》 2018-06
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Therapeutic Effect of Stem Cell-secreted Factors on Cutaneous Wounds in Dogs

JIANG Tao;WEI Zhao-hui;PU Hui;ZHANG Meng;ZENG Meng-ying;ZHANG Di;GAO Hong;YAN Yu-lin;College of Veterinary Medicine,Yunnan Agricultural University;  
This study was designed to investigate the allogeneic bone marrow mesenchymal stem cell-derived factors(BMSCF)to treat canine cutaneous wounds,which provided a theoretical basis and technical support for the clinical application of canine stem cell therapy.We established the skin damage model in dogs and observed the clinical effect of stem cell-derived factors on cutaneous wounds.A total of 9 dogs were randomly divided into 3 groups and there were 3 dogs in each group:the control group,the BMSCF treatment group and the conventional drug treatment group.BMSCF were smeared on the surface of far advanced skin trauma of dogs.Heal condition of canine back skin was observed.The results showed that the average healing time was(27.66±0.87)d with stem cell-derived factors treatment;The residual areas in back skin of dogs were(8.043±0.124)cm~2/10 d,(3.317±0.105)cm~2/20 d,0 cm~2/30 drespectively,which were faster and better than that of two other groups(P0.05).Skin tissue slices also showed that the scar area of BMSC-F treatment group was smaller than that of others,and healing was complete and quick.These findings indicated that stem cell-derived factors accelerate healing of the fascial and cutaneous incisional wounds and may provide a powerful technique to augment healing of clinically problematic wounds.
【Fund】: 校企合作项目(2017530117000288)
【CateGory Index】: S858.292
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