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《Journal of Chinese Electron Microscopy Society》 1992-01
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Electron Microscopic Observation on Morphological Charateristics of Invasion of Human Nasopharyngeal Cancer Cells in Vivo

Wang Fuxi Peng Longxiang Zuo Xiaojing (Laboratory of Electron Microscopy,Hunan Medical University) (Laboratory of Electron Microscopy,Shanghal Institute Pharmaceutical Industry)  
This article describes the morphological charateristies of nasopharyngeal cancer cells invasion proved by electron microscopy. The results suggested that the processes of invasion of the nasopharyngeal cancer cells can be divided into three stages, namely:a, the cytoplasmic base of anaplasia cells or cancer cells extended numerous filopodia, the latter lead tO waves or/and local loss of basement membrane, then, cancer cells by thire pseudopodia through defective basement membrane penetrated into the underlying interstitial stroma; b, because cancer cells possess capable of ac-tive locomotion, the invading cancer cells by amiboid movement actively migrate into the direction of least resis-tance, and the cancer cells will proliferate when active translatory movement cease, such migration/proliferation cy-cle is repeated, and the tissue pressure proliferating tumor lead to degradation of surrounding tissues; C, the in-vading cancer cells penetrated wall of vessels for further distant metastasis, therefore invasion is an essential part of the metastatic process.
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