Study on the Expression of the β_1-Subgroup of Integrins in Normal Hepatocytes and Hepatocarcinoma Cells
Ye Xuting Zheng Zun Sha Jihong Yu Bingxue Xia Yuanyao(Department of Central Laboratory,Second Military Medical University,Shanghai 200433)
The expresssion and distribution of β_1-subgroup of integrins were studied by collodial gold immunoelectron microscopy in normal hepatocytes, hepatocarcinoma cells and the surrounding hepatocytes of carcinoma. It was showed that positive markers were present in normal hepatocytes and endothelial cells. A few positive markers were also found in hepatocarcinoma cells. In surrounding hepatocytes of hepatocarcinoma, the positive markers were evident increased. The relationship between metastasis of carcinoma, fibrogenesis and expression of β_1-subgroup of integrins were discussed in this paper.