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Electron Microscopical Observation of Infiltrative Growth of Cholangiocarcinoma in Rats

Ruan Youbing Wu Zhongbi Yang Mulan (Department of Ultrastructural Pathology, Research Center of Experimental Medicine, Tongji Medical University, 430030 Wuhan)  
The ultrastructural manifestation of infiltrating activity of cholangiocarcinoma induced by Nitrosomor-pholine in rats was electron microscopically observed.There was a lot of filamentous components found in the cytoplasm of infiltrating carcinoma cells. The intercellular spaces between tumor cells were markedly widend.The carcinoma cells showed an elongated nucleus and many pseudopodia on their surface suggesting ameboid movement and infiltrating growth activity of these cells. The carcinoma cells broke finally the basement mem-brane and reached the adjacent capillaries.All three cases of cholangiocarcinoma observed showed a regular polarity and intercellular connections of tumor cells, they should be classified to the well differentiated category.
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