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Studies on relationship between myc family oncogene overexpression and prognosis of lung cancer

Bai Li , Sun Yan, Li Shende. Chinese PLA General Hospital & Military Post graduate Medical School,Beijing 100853, P.R.China  
Objective To evaluate the relationship between myc family oncogene overexpression and the clinical prognosis of lung cancer. Methods A series of 47 primary lung cancer specimens was analyzed for myc family oncogenes by RT PCR nondenature polycrylamide gel electrophoresis. Results There was a positive correlation between overexpression of myc oncogenes and tumor size,lymph node metastasis and stages of lung cancer.18 of 24 patients(75%) with myc overexpression showed relapse, which was higher than that (47%) without myc gene overexpression for one year postoperatively. The results also showed that 19 of 27 cases (70%) with myc gene overexpression had p53 alteration, and that 63% and 76% of these 19 cases was in stage Ⅲ and relapsed respectively, which was higher than that (27% and 22%) of the patients with p53 alteration but no myc gene overexpression. Conclusion myc family gene overexpression may be regarded as one of the prognostic determinants in lung cancer.
【CateGory Index】: R734.2
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