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Allele specific chromosome 3p25 deletion detected by PCR LOH analysis in non small cell lung cancer

Guan Saifang ,Xu Kaili, Liao Meilin, et al. Shanghai Cancer Institute, Shanghai 200032, P.R.China  
Objective To ascertain whether the loss of heterozygosity (LOH) of allele on chromosome 3p25 region is associated with non small cell lung cancer (NSCLC). Methods 3p25 LOH was analysed in patients with NSCLC by polymerase chain reaction based assays for dinucleatide repeat polymorphisms. Results Eighty out of 158(50.6%) cancer tissues of NSCLC were found to have 3p25 LOH, but no 3p25 LOH was observed in 5 normal fetal lung tissues and 4 tissues of the benign lung neoplasms. The deletion was detected in 62.0% of adenocarcinoma and 43.2% of the squamous carcinoma, indicating that the former was significantly higher than the latter (P0.05) . Loss frequences for TNM stages were further observed in 52.2%, 45.0% and 52.8% of the cases for stage Ⅰ,Ⅱ and Ⅲ respectively, and these data showed no significant relationship between the loss frequence and TNM staging of NSCLC (P0.05). Conclusion Above findings display that 3p25 LOH appear to be a common structural alteration occurred in NSCLC and there may be suppressor genes relevant to the carcinogenesis of the lung in 3p25 region.
【Fund】: 上海市医学领先学科和上海市科委课题
【CateGory Index】: R734.2
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【References】
Chinese Journal Full-text Database 1 Hits
1 GUAN Saifang, XU Kaili, ZHAO Ming, CHEN Fuhua, ZHOU Jin. Shanghai Cancer Institute, Shanghai 200032, P.R.China;Allele specific chromosome 3p deletion in primary non small cell lung cancer[J];CHINESE JOURNAL OF LUNG CANCER;2000-01
【Secondary References】
Chinese Journal Full-text Database 4 Hits
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4 Li Hong Zhao Ming Bai Yanjun et alShanghai Cancer Institute, Shanghai;Loss of Heterozygosity at Chromosome 3p in Microdissected Non-Small Cell Lung Cancer[J];Chinese Journal of Clinical Oncology;2004-03
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