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A study on the relationship between HPV infection and the oncogenesis of primary squamous carcinoma of the lung

Yang Yuhao,Dong Deqiong, Peng Linian, et al. Department of Respiratory Medicine, Affiliated Hospital of Zunyi Medical College,Zunyi 563003, P.R.China  
Objective To research the relationship between human papillomavirus(HPV) infection and the oncogenesis of primary squamous carcinoma of the lung. Methods 50 formalin fixed paraffin embedded tissues of squamous cell carcinoma of the lung, 30 samples of areas of squamous epithelium metaplasia near tumors, and 30 samples of normal bronchial mucosa were detected for the presence of HPV DNA by polymerase chain reaction (PCR).Results In these samples, the positive detection rate of HPV DNA was 26%,36.7%and 10% respectively. Of the detected HPV DNA, HPV16 was of the highest ratio. The positive rate of HPV6/11 and HPV16 in squamous cell carcinoma and squamous epithelium metaplasia had no significant difference by χ 2 test (P0.05). Conclusion These results suggest that HPV infection might play an important role in the oncogenesis of squamous cell carcinomas of the lung, and squamous epithelium metaplasia of the bronchus could be regarded as a precancer lesion. Compared with biotinylated DNA probes and hybridization technique, PCR has a higher sensitivity.
【Fund】: 贵州省教委资助课题! (C - 0 98)
【CateGory Index】: R734.2
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