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A study on the relationship between lung cancer cell apoptosis and prognosis in patients with human non small cell lung cancer

Li Lu, Zhou Qinghua, Luo Deyun, et al. Cancer Center, The First University Hospital, West China University of Medical Sciences, Chengdu, Sichuan 610041, P.R.China  
Objective To explore the relationship between the apoptotic level of lung cancer cell and oncogenesis, development and prognosis of lung cancer.Methods The apoptotic level of lung cancer cell was detected in 124 non small cell lung cancer samples, and their normal lung tissues adjacent to cancer and 40 normal pulmonary tissues as control by TUNEL.Results (1)The apoptotic index (AI) in the lung cancer tissues was significantly lower than that in the normal tissues adjacent to lung cancer and normal lung tissues (P0.01);(2)The AI of lung cancer cell was closely related to P TNM stages, lymph node involvement of the cancer (P0.05),but no close relation was observed among the AI, histological classification, cancer differentiation, size of the primary tumor, site of the cancer, age, sex of patients and smoking or not (P0.05);(3)The 5 year survival rate (45.57%) of patients in high AI group was significantly higher than that (14.69%) in lower AI group (P0.01).Conclusion Apoptotic suppression of lung cancer cells may play an important role in the oncogenesis, development and prognosis of lung cancer. Detection of apoptosis of lung cancer cells might be helpful to predict prognosis and guide the postoperative treatment in patients with lung cancer.
【Fund】: 国家自然科学基金资助! ( 39670 71 8)
【CateGory Index】: R734.2
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Chinese Journal Full-text Database 4 Hits
1 ZHOU Qinghua, LIU Lunxu, LI Lu, WANG Yun, CHEN Jun, YANG Jinlong. Cancer Center, The First University Hospital, West China University of Medical Sciences, Chengdu, Sichuan 610041, P.R.China;The transcript expression of PKC-β_1 gene in human lung cancer[J];Chinese Journal of Lung Cancer;2000-05
2 CHENG Zhe,WANG Jing,XING Lihua,et alDepartment of Respiratory, the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052,China;Significance and Expression of Bax in Non-small-cell Lung Cancer[J];Journal of Medical Forum;2006-03
3 LUO Zuyan, LIU Zijiang, YUAN Jianhua, et al. Department of Radiology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China;Study on the apoptosis of non-small cell lung cancer (NSCLC) after interventional treatment[J];Journal of Interventional Radiology;2001-01
4 ZHENG Maogen,LIANG Guangyu(Affiliated Hospital of North China Coal Medical College,Tangshan 063000);Significance of propein expression of pro-apoptotic Bax gene in nonsmall cell lung cancer[J];Journal of North China Coal Medical College;2004-03
Chinese Journal Full-text Database 10 Hits
1 GAO Shu - qing, SHAN Bao - en , ZHAO Ze - zhen, et al (1.Department of nutrition, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China; 2.Hebei Cancer Institute, Shijiazhuang 050011, China; 3. Preventive College of Hebei Medical University, Shijiazhuang 050017, China);An Experimental Study on the Immunoregul ating Acting of four Seaweed's Extracts in vitro[J];Carcinogenesis,Teratogenesis and Mutagenesis;2004-01
2 XIE Bing-fen LIU Zong-chao PAN Qi-chaoLIANG Yong-ju SU Xiu-rong(Cancer Institute, Sun Yat-Sen University of Medical Sciences, Guangzhou, 510060)WANG Li-kai(Department of Biochemistry. Sun Yat -Sen University of Medical Sciences)ZHANG Run-mei ZHANG Hong-da((Department of Biology, Zhongshan University);THE ANTICANCER EFFECT AND ANTl-DNA TOPOISOMERASE Ⅱ EFFECT OF EXTRACTS OF CAMELLIA PTILOPHYLLA CHANG AND CAMELLIA SINENSIS[J];Chinese Journal of Cancer;1992-06
3 MENG Zhi qiang, SONG Ming zhi, HUANG Wen xia, et al Department Hepatology,Cancer Hospital of Shanghai Medical University,Shanghai 200032,P R China;The effects of different drugs on telomerase activity of liver cancer cell[J];CHINESE JOURNAL OF CANCER;2000-04
4 TAN Xiao-hua; ZHANG Ya-li; ZHOU Dian-yuan(Institute for Hepatic Diseases, Beijing Army General Hospital, Beijing 100700, P R. China)(Institute for Digestive Diseases, Nanfang Hospital, The First Mlitary Medical University,Cuangzhou, 510515, P R. China);EGCG induced apoptosis and expression change of bcl-2 protein in gastric and hepatic carcinoma cells[J];CHINESE JOURNAL OF CANCER;2000-07
5 LI Jiang1* , YU Xin xin2, ZHENG Jian yong1, et al. 1.Department of Pathology, Fourth Military Medical University, Xi'an 710033, P.R.China 2.State Key Laboratory for Molecular Virology and Genetic Engineering, Beijing 100052, P.R.China;Overexpression of Bak gene may lead to apoptosis in hepatocellular carcinoma[J];CHINESE JOURNAL OF CANCER;2000-09
6 LUO Fei jun, HU Zhi, DENG Xi yun, GU Huan hua, CAO Ya* Cancer Research Institute of Hunan Medical University, Changsha 410078, P.R.China.;Tea polyphenols induce the activity of caspase-3 in nasopharyngeal carcinoma cells[J];Chinese Journal of Cancer;2000-12
7 WANG De-kun 1 ,ZHENG Jun-meng 2* ,JIANG Hai-ming 2 ,ZHANG Zhu-lin 3 ,ZHANG Jing-fang 4 ,OUYANG Neng-tai 5 .1.Cancer Institute of Zhongshan,Zhongshan 528403,P.R.China2.Department of Cardiothoracic Sur gery,Peoples Hosp;Expression of bcl-2in Lung Cancer:a Mechanism for Apoptosis Antagonism and Immune Evasion[J];Chinese Journal of Cancer;2001-02
8 ZHOU Qiong, BAI Ming, SU YuanDepartment of Respiratory Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Key Laboratory of PulmonaryDiseases, Health Ministry of China,Wuhan, Hubei, 430022, P. R. China;Effect of Antisense RNA Targeting Polo-like Kinase 1 on Cell Cycle of Lung Cancer Cell Line A549[J];Chinese Journal of Cancer;2005-02
9 Tan Xiaohua Zhang Yali Zhou Dianyuan, et al.Institute For Digestive Diseases, Nan Fang Hospital, The First military Medical University, Guangzhou 510515;Apoptosis of colon cancer cell line, LoVo, induced by green tea aqueous extract in vitro[J];CHINESE JOURNAL OF CANCER;1998-03
10 Xie Bingfen Liu Zongchao Hao Donglei, et alCancer Institute, Sun Yat Sen University of Medical Sciences, Guangzhou, 510060;The studies of cytotoxic effect and antitumor effect by TP[J];CHINESE JOURNAL OF CANCER;1998-06
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 WU Shan,SHENG Yan-liang,JIANG Zhi-xue,et al.Department of Surgery,The First Affiliated Hospital,China Medical University,Shenyang,110001,China;Clinical Significance of the Expression of Apoptosis and p53 in Lung Cancer[J];Journal of Chinese Physician;2003-05
2 Zhiqiang GAO, Baohui HANDepartment of Pulmonary Medcine, Chest Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200030, China;Protein Kinase C Inhibitor and Treatment of Non-Small Cell Lung Cancer[J];Chinese Journal of Lung Cancer;2009-01
3 SHI Jing yu, LI Bao xin, SUN Hong li, et al (Department of Pharmacology, Harbin Medical University, Harbin 150086, China);Variation of [Ca~(2+)]i induced by arsenic trioxide in human lung adenocarcinoma cell line[J];Journal of Harbin Medical University;2004-02
4 Xu Chuanshan Yu Qian Wu Shiming Pan Yinjun Niao Haiyang) (Dept.of Rehabilitation,Southwest Hospital,Third Military Medical University,Chongqing,400038);Effect of photodynamic therapy on the proliferating and metabolic status of human bladder cancer cell lines BIU-87 cells[J];Laser Journal;2002-06
5 XIA Xin-shu1,WU Shi-ming2,YU He-ping1,BAI Ding-qun1,TAN Yong3,HE Yong3,XU Chuan-shan3 (1.Department of Rehabilitation Medicine,First Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400016,China;2.Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China; 3.Institute of Ultrasound Imaging,Chongqing University of Medical Sciences,Chongqing 400010,China);Biological mechanisms of photodynamic therapy on tumor[J];Laser Journal;2008-05
6 HUANG Zicheng,CHEN Shengli Department of Intervention,the First Municilpal People's Hospital of Guangzhou,Guangzhou,Guangdong Province 510180,P.R.China;Analysis of Factors in the Prediction of Recent Curative Effect after BAI in Advanced Lung Carcinoma[J];Journal of Clinical Radiology;2008-05
7 WU Guangzhou,~1ZHENG Shiying,ZHU Tianzhong,et al (Department of Cardiothoracic Surgery,the Forth Hospital Affiliated to Nantong University,Yancheng 224006);Studies on the reverse of resistance using arsenic trioxide incombination with DDP in HTB-56/DDP cell lines of lung cancer[J];Journal of Nantong Medical;2005-06
8 LIN Hao1,HAN Bing2,HONG Guan-qiu1(1.Zhejiang Yunhe County People's Hospital,Yunhe 323600,China;2.Respiration department of the first hospital affiliated to Harbin Medical University.Harbin 150001,China);Apoptosis and LRP,MRP Gene Expression Induced by Arsenic Trioxide in lung adenocarcinoma cells[J];Strait Pharmaceutical Journal;2010-01
9 Liu Dongliang1,Ran Longjian2,Lu Yiping2,et al.1.363 Hospital,Chengdu,Sichuan 610041;2.West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China;Effect of different energy levels' holmium laser radiate inducing growth inhibition and apoptosis in T-24 bladder carcinoma cell[J];Sichuan Medical Journal;2007-08
10 LI Jian-ping1 , ZHANG Xiao-qing1,QI Yi-xin2 1Department of Biochemistry of the Basic Medical Dept. Xiangnan University, Chenzhou,Hunan 423000;2Surgery Department of Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang 050011 China.;The expression of protein kinase C isoenzymes in human breast cancer[J];Journal of Modern Oncology;2006-05
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