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Study on the deletion and mutation of p16 gene in human non small cell lung cancer

Du Ming,Li Liangbin,Zeng Zhaochun,et al.Department of Thoracic Surgery,The First Affiliated Hospital,Chongqing Medical University,Chongqing 400016,P.R.China  
Objective To study the relationship between the deletion and mutation of p16 gene and clinicopathologic manifestations of human non small cell lung cancer(NSCLC).Methods Silver staining PCR SSCP method of control amount of template DNA was used to detect exon 2 of p16 gene in human NSCLC tissue specimens.Results The deletion of p16 gene was identified in 13 out of 40 specimens. Of the 40 specimens, 3 showed a variant band indicative of the mutation. There was significant correlation between the frequency of the deletion and mutation (40%) and clinicopathologic stage (P0.05).Conclusion The deletion and mutation of p16 gene may play an important role in carcinogenesis,development and metastasis of human NSCLC.
【CateGory Index】: R734.2
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【References】
Chinese Journal Full-text Database 1 Hits
1 JlWei-dong, WU Zhong-liang, CHEN Jia-kun, Yl Fei, FENG Su-mei. Institute for Chemical Carcinogenesis, Guangzhou Medical College, Guangzhou 510182, China;Alteration of FHTT gene and P16 gene in malignant transformed cells induced by crystalline nickel sulfide[J];Chinese Journal of Oncology;2003-01
【Co-references】
Chinese Journal Full-text Database 2 Hits
1 JI Wei-dong, WU Zhong-liang, CHEN Jia-kun(Institute for Chemical Carcinogenesis of Guangzhou Medical College, Guangzhou 510182, China);MALIGNANT TRANSFORMATION OF HUMAN BRONCHIAL EPITHELIAL CELL LINE INDUCED BY CRYSTALLINK NICKEL SULFIDE[J];Carcinogenesis,Teratogenesis and Mutagenesis;2002-01
2 DUAN Xiao ming1, ZHANG Gui ying1, CHEN Zhu chu2* , et al. 1. Department of Gastroenterology, Affiliated Xiangya Hospital, Hunan Medical University,Changsha 410008, P.R.China 2. Laboratory of Tumor Cell Biology, Cancer Research Institute, Hunan Me;Abnormal expression of the FHIT gene in human primary colorectal cancer and colorectal cancer cell lines[J];CHINESE JOURNAL OF CANCER;2000-09
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Chinese Journal Full-text Database 3 Hits
1 CHEN Chuan-de, WU Zhong-liang, CHEN Jia-kun(Center for Disease Control and Prevention of Luohu district,Shenzhen, Shenzhen 518020, China; Institude forChemical Carcinogenesis, Guangzhou Medical College,Guangzhou 510182, China);Genomic Instability in Transformed 16HBE Cells Induced by Nickel Acetate[J];Carcinogenesis,Teratogenesis and Mutagenesis;2005-01
2 JI Wei-dong,CHEN Jia-kun,LU Jia-chun,WU Zhong-liang,FENG Su-mei,YI Fei(Institute for Chemical Carcinogenesis,Guangzhou Medical College,Guangzhou510182,China);Differential Protein Expression in Crystalline Nickel Sulfide-induced Malignant Transformed Cells by Two Dimensional Electrophoresis[J];Journal of Labour Medicine;2004-01
3 CHEN Chuan-de *,WU Zhon g-liang,CHEN Jia-kun,JI Wei-dong. *Center for Disease Control and Pr evention of Luohu District,Shenzhen 518020,China;Crystalline nickel sulfide-induced genomic instability in transformed human broncho-epithelial cells[J];Chinese Journal of Industrial Hygiene and Occupational Diseases;2004-01
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