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The expression of Bcl-2 gene in human lung cancer

Wang Yun,Zhou Qinghua,Zhang Wen,et al.Department of Thoracocardiac Surgery, The First University Hospital, West China University of Medical Sciences, Chengdu,Sichuan 610041,P.R.China  
Objective To explore the relationship between the Bcl 2 gene transcript expression and the oncogenesis, and development of lung cancer.Methods The expression of Bcl 2 mRNA was detected in 31 human lung cancer tissues, para cancer tissues, non cancer tissues and 13 benign lesion tissues by Northern blot.Results (1)The expression level of the Bcl 2 mRNA in the cancer tissues was significantly higher than that in the non cancer tissues and benign lesion tissues(P0.01), but there was no significant difference among the cancer and para cancer tissues,non cancer and benign lesion tissues, para cancer,non cancer and benign lesion tissues either(P0.05).(2)The Bcl 2 expression in poor differentiated lung cancers was significantly higher than that in moderate well differentiated lung cancers.(3)No significant difference was observed in Bcl 2 expression in different histoclassification of the cancer and P TNM stages of the cancer.Conclusion There is an overexpression of Bcl 2 mRNA in lung cancer tissues, and it may be involved in the oncogenesis and development of lung cancer.
【Fund】: 国家自然科学基金资助! (39670 71 8)
【CateGory Index】: R734.2
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